Joel A Block MD is the Willard L. Wood, MD, Professor of Rheumatology, professor of Medicine and of Biochemistry, and Director of the Division of Rheumatology at Rush University Medical Center. His early research focused on cartilage biology and chondrocytic proteoglycans, and several of his human chondrocyte cell models remain in use in laboratories on four continents. His interests subsequently broadened to include the role of aberrant biomechanical loading in lower extremity osteoarthritis. He leads a large multidisciplinary group that studies osteoarthritis from a broad perspective, including joint tissue biology, physiology of pain and mechanical mediators of osteoarthritis progression, all with the focus on identifying novel therapeutic strategies. He serves as Editor in Chief of Osteoarthritis and Cartilage and is a member of the Editorial Boards of the Journal of Orthopaedic Research and the Journal of Clinical Rheumatology.