PCSK9 Inhibitors: A Patient Case Curriculum
Inhibitors of the PCSK9 protein represent an important new therapeutic class for patients with familiar hypercholesterolemia or established CVD who require further LDL-C lowering beyond what statins can provide. This Case Curriculum illustrates two patient scenarios for the use of PCSK9 inhibitors, and reviews selection of patients who require more intensive LDL-C lowering and clinical efficacy and safety data for these novel agents.
Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships to disclose.
Speakers Bureau for Genzyme and sanofi-aventis U.S. Contracted Research for Genzyme; sanofi-aventis U.S.; and Retrophin, Inc. Consultant for Genzyme; Kaneka Corporation; Lilly, Retrophin, Inc.; and sanofi-aventis U.S.
Speakers Bureau for Aegerion Pharmaceuticals Inc.; Alexion Pharmaceuticals; Amgen, Inc; AstraZeneca; Genzyme; Merck & Co., Inc.; and sanofi-aventis U.S. Medical Advisory Board for Aegerion Pharmaceuticals Inc.; Akcea Therapeutics; Amgen, Inc.; Genzyme; Lilly; and sanofi-aventis U.S. Contracted Research for Aegerion Pharmaceuticals Inc. and Pfizer, Inc. Consultant for Amgen, Inc. and Amarin Corporation.
From Horizon CME, Brian Lee, PharmD, and Cara Williams, PharmD, have no relevant relationships to disclose.
sanofi-aventis U.S. and Regeneron Pharmaceuticals.
The opinions, ideas, and recommendations expressed in this educational activity are those of the faculty only and are not necessarily endorsed by, nor do they necessarily reflect, those of their affiliated institutions, pmiCME, pmiCME Advisory Boards and Consultants, DBC Pri-Med, LLC, or Vindico Medical Education.
Clinical judgment must guide each clinician in weighing the possible risks, benefits, or contraindications of any diagnostics, interventions or treatments discussed. Clinicians should review manufacturers’ product information and consider these with the recommendations of other authorities when applying the assessment and/or clinical management strategies discussed in this activity to the care of their patients.
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Discussion of Off-Label Uses and Investigational Products
During the course of their presentations, the faculty may mention uses of products that have not been approved in the United States for the indication(s) being discussed. All presenters are instructed to notify participants when they are discussing unapproved uses or investigational agents. In addition, specific slides will include notation of the off-label use or investigational agent being discussed. Views presented related to unapproved uses of products are solely those of the presenter(s) and are not endorsed by pmiCME or DBC Pri-Med, LLC.
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