In this case presentation, Dr. James Underberg, Clinical Assistant Professor of Medicine at NYU School of Medicine & NYU Center for Prevention of Cardiovascular Disease and Director, Bellevue Hospital Lipid Clinic, shares strategies for identifying Heterozygous Familial Hypercholesterolemia (HeFH) in a patient with a lifelong history of elevated cholesterol. He also summarizes data for recently approved PCSK9 inhibitors for treating patients with HeFH.

Learning Objectives

  • Implement optimal medical therapy for patients with hypercholesterolemia based on the latest guideline recommendations and clinical data.
  • Discuss the role of PCSK9 in LDL-C metabolism and as a therapeutic target for the treatment of hypercholesterolemia.   
  • Evaluate recent clinical trial data and the role of PCSK9 inhibitors in reducing cardiovascular risk among various patient groups with hypercholesterolemia.

Faculty Disclosures

James A. Underberg, MS, MD, FACPM, FACP, FASPC, FNLA

Speakers Bureau for Aegerion Pharmaceuticals Inc.; Alexion Pharmaceuticals; Amgen, Inc; AstraZeneca; Genzyme; Merck & Co., Inc.; and sanofi-aventis U.S. Medical Advisory Board for Aegerion Pharmaceuticals Inc.; Akcea Therapeutics; Amgen, Inc.; Genzyme; Lilly; and sanofi-aventis U.S. Contracted Research for Aegerion Pharmaceuticals Inc. and Pfizer, Inc. Consultant for Amgen, Inc. and Amarin Corporation.


Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships to disclose.

From Horizon CME, Brian Lee, PharmD, and Cara Williams, PharmD, have no relevant relationships to disclose.

Commercial Supporters

sanofi-aventis U.S. and Regeneron Pharmaceuticals

Education Partner

Horizon CME

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