Overview

In this case presentation, P. Barton Duell, M.D., Director, Lipid Disorders Clinic and LDL Apheresis, and Director, Lipid-Atherosclerosis Laboratory at the Knight Cardiovascular Institute at Oregon Health and Science University, shares strategies for assessing cardiovascular risk and customizing lipid lowering therapy in an asymptomatic physically active 66 year-old man with mildly elevated LDL cholesterol and a strong family history of cardiovascular disease. Dr. Duell also discusses use of recently approved PCSK9 inhibitors for cholesterol reduction in patients with established cardiovascular disease.  

Learning Objectives

  • Outline the differences between the 2013 AHA/ACC guideline recommendations and those from other hypercholesterolemia treatment guidelines. 
  • Implement optimal medical therapy for patients with hypercholesterolemia based on the latest guideline recommendations and clinical data. 
  • Discuss the role of PCSK9 in LDL-C metabolism and as a therapeutic target for the treatment of hypercholesterolemia.   
  • Evaluate recent clinical trial data and the role of PCSK9 inhibitors in reducing cardiovascular risk among various patient groups with hypercholesterolemia.

Faculty Disclosures

P. Barton Duell, MD, FNLA, FAHA

Speakers Bureau for Genzyme and sanofi-aventis U.S. Contracted Research for Genzyme; sanofi-aventis U.S.; and Retrophin, Inc. Consultant for Genzyme; Kaneka Corporation; Lilly, Retrophin, Inc.; and sanofi-aventis U.S. 

Disclosures

Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships to disclose.

From Horizon CME, Brian Lee, PharmD, and Cara Williams, PharmD, have no relevant relationships to disclose.


Commercial Supporters

sanofi-aventis U.S. and Regeneron Pharmaceuticals

Education Partner

Horizon CME


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