InLight
  • Medical Conferences
  • Online Education
  • Virtual CME/CE Programs
  • ConnectED Learning
  • Podcast
  • Clinical Resources
  • About
  • Contact Us
  • Login

  • Partners

  • Exhibitors
  • Content Contributors

  • Pri-Med Job Board

  • Learn. Grow. Thrive. When it's time to make a change, Pri-Med Job Board is here to connect you with primary care jobs from top employers. 

Pri-Med
  • Join
  • Log In
  • Search
  • Menu
  • Home
  • Clinical Resources

Changes in Risk Indicators of MetS Severity Tied to T2DM Risk

For patients with prediabetes, changes in risk indicators during intervention tied to T2DM, CVD risk

  • November 15, 2018 (Last Updated)
Article Image

WEDNESDAY, Nov. 14, 2018 (HealthDay News) -- For patients with prediabetes who are randomly assigned to interventions, changes in risk indicators of metabolic syndrome (MetS) severity are associated with the risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), according to a study published in the November issue of Diabetes Care.

Mark D. DeBoer, M.D., from the University of Virginia in Charlottesville, and colleagues analyzed data for 2,476 adults from the Diabetes Prevention Program with prediabetes who were randomly assigned to receive lifestyle modification, metformin, or placebo. Effect sizes were calculated from baseline in a MetS severity z score (MetS-Z) and the individual MetS components. The authors assessed the correlations between effect sizes and incident T2DM and CVD.

The researchers found that baseline MetS-Z and its components correlated with the risk for incident T2DM and CVD. During year one of intervention, the greatest decrease in MetS-Z and its components was seen with lifestyle modification, followed by metformin and placebo. The strongest association was seen for risk for T2DM within one to five years with one-year changes in MetS-Z and waist circumference; the risk fpr CVD correlated with one-year change in MetS-Z, glucose, and systolic blood pressure. One-year changes in MetS-Z, waist circumference, glucose, and triglycerides mediated the effect of lifestyle modification on T2DM risk; MetS-Z and glucose mediated the effect of metformin.

"These factors may serve as important biomarkers of metabolic disarray to identify individuals at highest risk and track the response to treatment," the authors write.

Abstract/Full Text (subscription or payment may be required)


Health Day News

Pri-Med is a medical education company that provides practical answers to facilitate better patient outcomes

Corporate

  • About
  • News
  • Contact Us

Products

  • Medical Conferences
  • Online Education
  • Clinical Resources

Partners

  • Exhibitors
  • Content Contributors

© 2019 DBC Pri-Med LLC | Privacy & Ethics | Terms & Conditions