This initiative aims to increase understanding of adjunctive LDL-C-lowering therapies and their potential role in reducing residual ASCVD risk. National lipid expert faculty will discuss the incidence of and diagnostic criteria for statin intolerance, explain the mechanistic rationale for lowering LDL-C through nonstatin therapies, explore novel targets and treatment pathways, and apply the 2018 AHA/ACC Cardiology Cholesterol Guidelines. Learners will gain practical clinical perspectives during expert case study discussions, including how new treatment options may fit into the current therapeutic landscape. 

Please note that any data, indications, and guidelines presented in this activity are current as of the recording/release on 09/24/2020 and they are subject to change as new information is published.


Learning Objectives

  • Discuss residual atherosclerotic cardiovascular disease (ASCVD) risk, including increased risk among patients with familial hypercholesterolemia (FH) or statin intolerance.
  • Apply recommendations from the 2018 American Heart Association (AHA)/American College of Cardiology (ACC)/Multisociety Cholesterol Guideline for managing hypercholesterolemia in patients for whom the response to maximally tolerated statin monotherapy may be inadequate.
  • Assess the clinical trial data supporting new LDL-C-lowering therapies.
  • Articulate the potential role of emerging non-statin drug therapies in the management of patients with hypercholesterolemia, including those with FH or others in whom the response to maximally tolerated statin monotherapy may be inadequate.



Peter Libby, MD

Mallinckrodt Professor of Medicine at Harvard Medical School
Cardiovascular specialist at Brigham and Women’s Hospital
Boston, MA 

Erin Bohula, MD, DPhil

Associate Physician in Cardiovascular Medicine Brigham and Women's Hospital
Instructor of Medicine at Harvard Medical School
Boston, MA 

Kevin Maki, PhD, CLS, FNLA, FTOS, FACN

Midwest Biomedical Research a 
Division of MB Clinical Research and Consulting LLc.
Indiana University School of Public Health 
Bloomington, Indiana 


The following relevant financial relationships have been disclosed by faculty: 

Peter Libby, MD: Advisory Board: Amgen, Corvidia Therapeutics, DalCor Pharmaceuticals, Kowa Pharmaceuticals, Olatec Therapeutics, Novartis, and XBiotech, Inc.

Erin Bohula May, MD: Advisory Board: Amgen, Novo Nordisk, Kowa Pharmaceuticals, and Servier, Contracted Research: Amgen

Kevin C. Maki, PhD, CLS, FNLA, FTOS, FACN: Consultant: Acasti, Corvidia Therapeutics, Matinas Biopharma, Pharmavite, and 89Bio

Non-faculty contributors involved in the planning, development, editing, and review of the content have disclosed no relevant financial relationships.

CME/CE Information

AMA PRA Category 1 Credits

Accreditation Statement

Pri-Med Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation Statement

Pri-Med Institute designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation Standards of the American Association of Nurse Practitioners (AANP) through the joint providership of Pri-Med Institute and Integrity CE. Pri-Med Institute is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider Number 040308.

Designation Statement

This program has been approved for 1.00 contact hour of continuing education, including 1.00 hour of pharmacology. 

Instructions for Obtaining Credit

Once you have completed the activity, please click the "next" button to advance to the post-activity assessment. To complete this activity and claim credit, you must answer 4 out of the 5 questions correctly. If you are not successful after your first attempt, you will be given an opportunity to reflect upon the answer rationales and have the opportunity to review the educational content before proceeding. Once you have selected your answers, click the "submit" button to complete the evaluation questions and proceed to the claim credit screen.

MOC Credit Information

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. 

Commercial Supporter

Esperion Therapeutics, Inc.

Education Partner

Integrity CE

Fine Print

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The opinions, ideas, and recommendations expressed in this educational activity are those of the faculty only and are not necessarily endorsed by, nor do they necessarily reflect, those of their affiliated institutions, Pri-Med Institute, Pri-Med Institute Advisory Boards and Consultants, DBC Pri-Med, LLC.

Clinical judgment must guide each clinician in weighing the possible risks, benefits, or contraindications of any diagnostics, interventions or treatments discussed. Clinicians should review manufacturers’ product information and consider these with the recommendations of other authorities when applying the assessment and/or clinical management strategies discussed in this activity to the care of their patients.

Pri-Med Institute educational activities are developed and conducted in accordance with the ACCME's Essential Areas and Policies. It is the mission of Pri-Med Institute to develop and present educational activities that are timely, fair-balanced, scientifically rigorous, and that serve to improve patient outcomes. To that end, we welcome your comments about how to better serve your needs.

Pri-Med Institute Accredited Provider
Pri-Med programs are owned and operated by DBC Pri-Med, LLC, a division of Diversified Communications, Inc. Pri-Med Institute, the accredited division of Pri-Med, is accredited with commendation by the ACCME and approved as a provider of continuing education by the AANP. Pri-Med Institute is the accredited provider for this activity.

Disclosures and Conflict of Interest
Pri-Med Institute requires all individuals in a position to influence educational content for Pri-Med Institute-certified CME/CE activities to disclose relevant personal financial relationships with commercial interests prior to contributing to its educational activities. Pri-Med Institute assesses disclosed relationships and follows a defined process to resolve real or implied conflicts to ensure, to the best of its ability, that all educational content is free of commercial bias. Financial disclosures are listed in the activity syllabus and will also be printed on the slides and announced at the start of each presentation.

Discussion of Off-Label Uses and Investigational Products
During the course of their presentations, the faculty may mention uses of products that have not been approved in the United States for the indication(s) being discussed. All presenters are instructed to notify participants when they are discussing unapproved uses or investigational agents. In addition, specific slides will include notation of the off-label use or investigational agent being discussed. Views presented related to unapproved uses of products are solely those of the presenter(s) and are not endorsed by Pri-Med Institute or DBC Pri-Med, LLC.

Questions? If you have questions about this activity, please email support@pri-med.com or call (877) 477-4633.