Theodore Pincus is Professor of Medicine at Rush University in Chicago, having served on faculties at Cornell, Stanford, University of Pennsylvania, Vanderbilt, and NYU. His early laboratory research included development of a radioimmunoassay for DNA antibodies as a simple clinical test for systemic lupus erythematosus (SLE), and recognition of genes that control experimental retrovirus infection. In 1982, he recognized severe functional declines and premature death in rheumatoid arthritis (RA), predicted most significantly by patient physical function scores and by low socioeconomic status. He documented that early methotrezate and 3 mg prednisone improved RA outcomes considerably. He has developed patient MDHAQ/RAPID3 and physician RheuMetric to improve workflow in clinical settings and record clinical information as quantitative, standard, robust "scientific" data, beyond narrative descriptions, informative in all rheumatic diseases, and possibly all chronic diseases. MDHAQ scores indicate that disease burden in patients with osteoarthritis is similar to that seen in patients with RA.