This initiative aims to increase understanding among cardiologists about adjunctive LDL-C-lowering therapies and their potential role in reducing residual ASCVD risk. During this series, national lipid expert faculty will discuss the incidence of and diagnostic criteria for statin intolerance, explain the mechanistic rationale for lowering LDL-C through nonstatin therapies, and explore novel targets and treatment pathways. It is expected to improve cardiologists’ management of patients with ‘tough-to-treat’ cholesterol according to the 2018 American Heart Association (AHA)/American College of Cardiology (ACC)/Multi-society Cholesterol Guidelines. Learners will have the opportunity to gain practical clinical perspectives during expert case study discussions. The patient scenarios will discuss how new treatment options may fit into the current therapeutic landscape.