The development of cardio-oncology as a clinical field has been driven by improved therapeutics resulting in a dramatic increase in the number of cancer survivors (~17,000,00 in the United States alone) many of whom suffer cardiovascular complications related to their cancer treatments. Both "traditional" and "targeted" therapies can affect the cardiovascular system resulting in hypertension, heart failure, myocarditis, arrhythmias, vascular disease, and thrombosis. While recurrence of cancer is the eventual cause of death in many "cancer survivors", cardiovascular disease is responsible for substantial morbidity and mortality in this population. Thus, effective means of mitigating cardiovascular complications of cancer therapies would have substantial impact on health. Here we will review novel issues in cardio-oncology and will give a broad overview of this emerging field.